Generation of a Persistently Infected MDBK Cell Line with Natural Bovine Spongiform Encephalopathy (BSE)
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چکیده
منابع مشابه
Generation of a Persistently Infected MDBK Cell Line with Natural Bovine Spongiform Encephalopathy (BSE)
Bovine spongiform encephalopathy (BSE) is a zoonotic transmissible spongiform encephalopathy (TSE) thought to be caused by the same prion strain as variant Creutzfeldt-Jakob disease (vCJD). Unlike scrapie and chronic wasting disease there is no cell culture model allowing the replication of proteinase K resistant BSE (PrPBSE) and the further in vitro study of this disease. We have generated a c...
متن کاملBovine Spongiform Encephalopathy (BSE)
Detailed tables containing information on countries in which BSE has been reported are provided by the World Organisation for Animal Health (OIE) on its website (BSE specific data – www.oie.int). Apart from the 184 169 cases in cattle that were diagnosed in the UK up to the end of 2011, 20 other European countries also recorded the disease, some such as Portugal, Switzerland and Ireland at high...
متن کاملEpidemiological Analysis of Bovine Spongiform Encephalopathy (bse)
Bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep and goats, chronic wasting disease (CWD) in cervids, and Creutzfeldt-Jakob disease (CJD) in humans are known as prion diseases or transmissible spongiform encephalopathies (TSE), which cause neurodegenerative disorders. BSE was first reported in the United Kingdom (UK) in 1987, following which over 180,000 cases have been report...
متن کاملBSE--bovine spongiform encephalopathy ('mad cow disease').
About BSE BSE (bovine spongiform encephalopathy) is a progressive neurological disorder of cattle that results from infection by an unusual transmissible agent called a prion. The nature of the transmissible agent is not well understood. Currently, the most accepted theory is that the agent is a modified form of a normal protein known as prion protein. For reasons that are not yet understood, t...
متن کاملBovine Spongiform Encephalopathy (BSE) – Mad Cow Disease
The background to the epidemic of bovine spongiform encephalopathy (BSE) among cattle in the United Kingdom is described as the possible origin of the disease and its relationship to scrapie in sheep. Although the epidemic in cattle is virtually over there is evidence of the transmission of the infectious agent to humans to produce a new variant of Creutzfeldt-Jakob disease. The current status ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0115939